combined effect of swimming training and arbutin supplementation on kidney total oxidant and antioxidant status in alloxan-induced diabetic rats

objective:diabetes mellitus is a common metabolic disorder that is one of the important factors in the etiology of injuries oxidant know the purpose the aim of the present study, was the effect of swimming training with arbutin on total oxidant status (tos) and total antioxidant status(tas) the kidney tissue of alloxan-induced diabetic rats.methods: for this purpose, 42 male wistar rats with an average weight of 195 to 220 g were randomly divided into 6 groups(7 rats per group) of control, diabetic, arbutin, diabetic-arbutin, diabetic -swimming training and diabetic - combinatorial. swimming training protocol consisted of 5 day/week for 6 weeks and 5-36 min/day. diabetes was induced whit alloxan (90 mg/k g, intraperitoneally, ip) in rats and arbutin (50 mg/kg, subcutaneously) was administered for 5 days/week. the rats were killed 48 h after the last treatments and kidney tos and tas levels were evaluated. a one-way analysis of variance was used to data analysis.results: six weeks of supplementation with arbutin, swimming training and combination of swimming training and arbutin were associated with an significant decrease in tos (p